Beat the Depths/Necropolis without taking damage.
Kill Isaac with Eden.
Kill Satan with Eden.
Kill Satan with Lazarus.
Kill Isaac with Lazarus.
Kill Satan with Azazel.
Kill Isaac with Azazel.
Beat the Womb/Utero without taking damage.
You are the best!
Kill Isaac with Eve.
Kill Satan with Eve.
Kill Satan with ???.
Beat the Caves/Catacombs without taking damage.
Kill Isaac with Judas.
Kill Satan with Judas.
Kill Satan with Cain.
Beat Sheol 5 times.
Kill Mom.
Kill Isaac with Cain.
Kill Isaac with Samson.
Beat Cathedral 5 times.
Kill Satan with Samson.
Kill Isaac with Maggy.
Kill Satan with Maggy.
Beat the Basement 40 times.
Kill Isaac with Isaac.
Beat the Depths 20 times.
Kill Mom using the Bible.
Beat the Caves 30 times.
Kill Mom's Heart 11 times.
Kill Mom's Heart 10 times.
Kill Mom's Heart 9 times.
Kill Mom's Heart 8 times.
Kill Mom's Heart 5 times.
Kill Mom's Heart 3 times.
Beat 2 levels in a row without picking up any hearts.
Beat 2 levels in a row without taking damage.
Beat the Basement/Cellar without taking damage.
Hold 55 or more pennies at one time.
Kill Satan
Kill Satan with Isaac.
Have 7 or more max red hearts at one time.
Collect 2 of either Roid Rage, The Virus, Growth Hormones, Experimental Treatment, or Speed Ball.
Beat the Womb for the first time,
Kill all 7 sins.
Have 4 or more soul hearts at one time
Make 3 deals with the devil in one run.
Finish the game's final secret.
Kill Isaac with The Lost.
Kill Satan with The Lost.
Beat the Chest or Dark Room without taking damage.
Beat all 20 Challenges.
Beat the Boss Rush.
Beat the Dark Room.
Beat the Chest.
Beat the Dark Room with Isaac.
Collect all items and unlock all secrets and endings.
100% the game!
Beat Greed Mode with Azazel
Kill ??? with Lilith
Kill The Lamb with Lilith
Donate 1000 coins in Greed Mode
Kill ??? with Keeper
Kill The Lamb with Keeper
Collect all items and unlock all secrets
Unlocked a new area
Beat Delirium
Just Stop!
Kill Mega Satan
Donate 500 coins to the Greed Machine
Kill The Lamb
Uncover some lost remains..